Howel–Evans syndrome

Tylosis with esophageal cancer
Classification and external resources
OMIM 148500
DiseasesDB 33404

Howel–Evans syndrome (also known as "Familial keratoderma with carcinoma of the esophagus," "Focal non-epidermolytic palmoplantar keratoderma with carcinoma of the esophagus,"[1] "Palmoplantar ectodermal dysplasia type III," "Palmoplantar keratoderma associated with esophageal cancer," "Tylosis"[2]:213[3]:511, and "Tylosis–esophageal carcinoma"[1]) is an extremely rare condition in which the skin of the palms of the hands, and soles of the feet, are affected (hyperkeratosis).

It was characterized in 1958.[4]

A locus at 17q25 has been identified.[5]

See also

References

  1. ^ a b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0721629210.
  3. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
  4. ^ HOWEL-EVANS W, McCONNELL RB, CLARKE CA, SHEPPARD PM (July 1958). "Carcinoma of the oesophagus with keratosis palmaris et plantaris (tylosis): a study of two families". Q. J. Med. 27 (107): 413–29. PMID 13579162. http://qjmed.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=13579162. 
  5. ^ Langan JE, Cole CG, Huckle EJ, et al. (May 2004). "Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene". Hum. Genet. 114 (6): 534–40. doi:10.1007/s00439-004-1100-3. PMID 15007728. 

External links